The aldol condensation of acetone with acetophenone

The Aldol Condensation Preparation of 4-Methoxybenzalacetone

Organic Synthesis: Aldol Condensation Reaction

In an "aldol addition" reaction an enol or enolate of an aldehyde or ketone reacts with a second aldehyde or ketone forming a new carbon-carbon bond which makes the aldol reaction an important reaction for organic synthesis. Originally, the aldol reaction used ethanal (see below) and therefore the product contained both an aldehyde and an alcohol functional group; thus it became known as the al...

The Complete Mechanism of an Aldol Condensation.

Although aldol condensation is one of the most important organic reactions, capable of forming new C-C bonds, its mechanism has never been fully established. We now conclude that the rate-limiting step in the base-catalyzed aldol condensation of benzaldehydes with acetophenones, to produce chalcones, is the final loss of hydroxide and formation of the C═C bond. This conclusion is based on a stu...

Organic Synthesis: Aldol Condensation Reaction

In an "aldol addition" reaction an enol or enolate of an aldehyde or ketone reacts with a second aldehyde or ketone forming a new carbon-carbon bond. This makes the aldol reaction an important reaction for organic synthesis. Originally, the aldol reaction used ethanal (see below) and therefore the product contained both an aldehyde and an alcohol functional group; thus it became known as the al...

The Fluorescent Condensation Product of N’-methylnicotinamide and Acetone

In 1940 Najjar and Wood (1) detected the presence of an unknown substance appearing in human urine after the ingestion of nicotinic acid and nicotinamide. This material was isolated from urine by Huff and Perlzweig (2, 3) and was shown to be the ion N1-methylpyridinium-3carboxylic acid amide, designat,ed as N1-methylnicotinamide (I in Fig. 1). In an investigation of the chemical properties of t...